TMZ reports that Ensa Cosby died in Massachusetts, where the family has a large estate.
A spokesperson for her father, Andrew Wyatt, announced on Monday afternoon that her death was caused by renal disease, with Ensa having suffered from kidney problems throughout her life.
Her passing comes one month before her father is set to be retried on rape charges in Pennsylvania this April.
This is the second child Cosby has lost, with son Ennis having been murdered in 1997 during a botched carjacking in Los Angeles. Ensa is survived by her parents Bill and Camille, her siblings Erika, Erinn and Evin and her husband Martin McLean.